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54 The components of polysomnography can vary, but typically include 54,55 : Electroencephalography (EEG) to measure brain electrical activity and thereby evaluate sleep architecture Electrocardiogram (ECG) to monitor heart electrical activity Electro-oculography (EOG) to detect eye movements and provide further information about REM and other sleep stages Electromyography (EMG) to provide information about muscle tension and limb movements Airflow sensors to assess the movement of air through the nose and mouth to detect episodes of apnea (paused breathing) or hypopnea (shallow breathing) and other disordered breathing patterns Pulse oximetry to measure blood oxygen levels and help detect correlations between oxygen levels, breathing, and arousals during sleep Plethysmography to monitor respiratory mechanics Video and sound recordings to detect sleep position and sleep events such as nightmares or night terrors, sleep talking or walking, and other sleep movements and sounds After this data is collected, it is synthesized and analyzed in short time frames

From Dr Linsemans preclinical work in mice, Immunocal shows great promise

Enter vial size, target mass, and water volume, and it returns the precise units to measure

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J.VerschoyleR.LimC