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Circadian rhythms in the blood-brain barrier: impact on neurological disorders and stress responses
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Regardless I will share what I think is the best frequency to start using a retinoid at, no matter if its a lower concentration or higher concentration: 1-2x per week for the first 1-2 months 2-3x per week for the first 2-3 months 3-4x per week for the first 3-4 months Lots of people think you have to be using a retinoid daily for best results, but every other day is also fine
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