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Then, to ulteriorly determine how IGF-1 gene overexpression alleviated SIPS of hepatocytes, primary hepatocytes were transfected the IGF-1 adenovirus vector to overexpress IGF-1 (namely AV-IGF-1) or nontarget adenovirus vector (called AV-CTR), and then treated with H 2 O 2 (200 nM) for 24 h

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There is an ongoing phase 2/3 randomised, double-blind, placebo-controlled trial (NCT06126315) of the biological and clinical effects of acetyl-l-carnitine planning to recruit ~250 patients [88]