"The risk of developing these severe side effects is very small, but it is important that patients and healthcare professionals are aware and alert to the associated symptoms." In the UK, the most commonly used GLP-1 therapies are Novo Nordisk's semaglutide-based Ozempic for diabetes and Wegovy for obesity, as well as Eli Lilly's Mounjaro (tirzepatide), which are all given as weekly injections
Typical dosages range from 10-20 grams per day, but this can vary
On the tirzepatide front, while true generics are further behind due to more recent approvals and patent coverage, global players are already investing in manufacturing capabilities and early development work to position for eventual entry.
doi: 10.1016/j.biopha.2021.111315 70 HotamisligilGS
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