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A key consideration is that the cross-sectional nature of this study means we cannot draw any conclusions about the direction of effect: are changes in motivation the consequence of metabolic ill-health, or do they precede them

NGRA uses information from NAMs and conservative decision-making to protect human health, aligning with the way regulatory decision-making has been conducted using traditional approaches (Browne et al., 2024)

Key research areas include dual-pathway receptor signalling, glucose and metabolic response models, energy balance studies, controlled weight-related research, and interaction with cellular energy compounds

Mashima, T., Seimiya, H