Group 8 received local MSC and Dihexa via Hydrogel, an intravenous injection of MSC, and an injection into the gastrocnemius muscle with MSC dissolved in saline and Dihexa dissolved in DMSO
Surprisingly, when we compared wildtype and prx1 cells in these assays, we observed that prx1 cells were not more sensitive than wildtype cells at H 2 O 2 concentrations below 10 mM, while at higher H 2 O 2 concentrations, the presence of Prx1 was even found to be significantly detrimental (Appendix Fig S4L and M)
The severity profile matters more than the raw percentages
TM3 cells were harvested after treatment, stained with Annexin V-FITC and PI reagent, and incubated in the dark for 15 minutes
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