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There is no established evidence that continuous use is either necessary or safe over long horizons
Its favorable for cells to spread and survive despite therapy
Some temporary tiredness during this transition makes physiological sense
They make clinical sense when managing documented metabolic adaptation, addressing specific complaints of profound fatigue on GLP-1s, or when gastrointestinal side effects prevent the use of standard therapies
It does not require injection if oral bioavailability is adequate
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