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Unlike Ozempic and Wegovy, Rybelus is notable for being the first glucagon-like peptide-1 (GLP-1) receptor agonist available in pill form
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So the main limitation is not evidence of harm, but rather a lack of sufficient long-term, high-quality data to draw firm conclusions
10.1186/s12943-019-1035-x 75 MagyarK.HalmosiR.PalfiA.FeherG.CzopfL.FulopA.et al (2012)
Efficacy and safety of nivolumab plus ipilimumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib: the CheckMate 040 Randomized Clinical Trial
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