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[1] Severe gastrointestinal symptoms with signs of dehydration (markedly decreased urination, dizziness) require urgent evaluation due to risk of acute kidney injury

There have been years-long randomized clinical trials demonstrating that these drugs can lead to clinically meaningful and sustained weight loss as well as trials revealing that their use reduces the risk of a myriad of other medical conditions including heart attacks, strokes, fatty liver disease, kidney failure and more

But it's not all high heels and dream houses

The honest caveat is important: much of the evidence for these peptides is still preclinical, meaning animal and laboratory research, so they are best understood as a supervised, supportive option with realistic expectations rather than a proven cure