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2B), indicative of an elevation of GSH export in response to cystine starvation

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in diabetic rodents, Fan and colleagues [77] demonstrated that intravitreal exedin-4 injection reduced retinal cell loss, maintained Bcl-2/Bax ratios, whose imbalance is associated with retinal cell apoptosis, prevented activation of pro-apoptotic AKT, and prevented excess reactive gliosis

This reaction, when it occurs, typically reverses within two to four weeks of discontinuation

These are typical of any subcutaneous injection and generally resolve within a few hours