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Proposed criteria for efficacious therapeutics in PMS include penetration across the bloodbrain barrier, antagonism of compartmentalized lymphocytes and microglia/macrophages, and amelioration of oxidative stress
Radtke KK, Coles LD, Mishra U, Orchard PJ, Holmay M, Cloyd JC
Summary: Vitamin B12 injections for pernicious anaemia deliver hydroxocobalamin intramuscularly to bypass malabsorption caused by lack of intrinsic factor, rapidly correcting deficiency and preventing neurological damage
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It can make it harder to know which compound is helping, which one is causing side effects, and how the overall protocol should be adjusted
