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GLP-1 in addiction medicine: GLP-1 acts on pancreas, gut, kidney, heart and thyroid receptors to activate reward/stress hubs (VTA, NAc, ARC, PFC, hypothalamus)
Key Takeaways IGF-1 LR3 has a half-life of roughly 20 to 30 hours versus native IGF-1's roughly 12 to 15 hours, due to reduced binding protein affinity, giving it the strongest mechanistic case for direct anabolism among research peptides
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The Lancet (2021) 6
Figures 4(a) and (b))
Concentrations of the active intact hormones are increased by JANUVIA, thereby increasing and prolonging the action of these hormones
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