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Taylor SI, Blau JE, Rother KI, Beitelshees AL (2019) SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks

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In phase 2 clinical trials published in the New England Journal of Medicine (2023), it demonstrated substantial weight loss outcomes, largely attributed to its ability to influence hunger signals particularly in the hypothalamus, which governs satiety and energy balance