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Hypertens Res 48 , 31593171 (2025)
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Notably, OCT1, PMAT, and SERT are the principal transporters facilitating metformins intestinal absorption in intestinal cells, contributing to 25%, 20%, and 20% of its transport, respectively (Han et al., 2015)
cis -regulatory elements potentially important for differential transcriptional regulation of the RcGPXs
However, further research is needed to understand their full potential and all details of their mechanism of action, which will enable to expand the therapeutic indications and to determine their optimal use in clinical practice
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