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When used for weight management, the evidence increasingly supports long-term or indefinite treatment for patients who respond well and tolerate the medication particularly those with obesity-related cardiovascular risk factors

however, the precise contribution of this pathway in humans is not yet fully characterised

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This trend aligns with national dispensing patterns, where a study reported a nearly 600% increase in GLP-1 RA prescription fills among adolescents and young adults from 2020 to 2023 ( 9 ) and our own research, which has shown that GLP-1 RAs now make up over 5% of all prescriptions prescribed

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