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ROS is observed in the activation of MMP-2, potentially by the reaction of oxygen radicals with thiol groups found in MMP-2 (126, 127)

Accordingly, from this perspective, GDM is now seen as a chronic metabolic disorder that holds implications across the life span of both mother and child

154 However, HIF-1 in islets is decreased in T2D, by hyperglycemia through inhibiting the HIF-1-HIF-1 dimer formation, and by NEFAs through increasing the proteolysis, leading to inability to initiate hypoxic adaptive responses