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In healthy tissue, the peptide maintains NO homeostasis by modestly increasing endothelial NOS (eNOS) for beneficial vasodilation while suppressing inducible NOS (iNOS) that drives pathological inflammation

SURMOUNT-1 Trial: Tirzepatide for Weight Reduction in Obesity - Primary clinical trial data on tirzepatide efficacy and adverse events

These results suggest that the mGIPR-Ab and GLP-1 components of the peptideantibody conjugate target and differentially modulate activation of different cell subpopulations in the AP

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