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So far, however, B cell-directed agents have not been tested in the early disease stage, precluding conclusions regarding the usefulness of such interventions in delaying or even preventing progression to later stages

Published studies show that choline supports VLDL assembly and prevents hepatic steatosis, inositol improves insulin sensitivity in PCOS models, methionine provides methyl groups for hepatic detoxification, and B12 supports energy metabolism

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(2) Elevation of Oxidative Damage Markers Analysis of oxidative damage markers revealed significant alterations in the VPA-exposed group