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[53] A 2026 systematic review and meta-analysis found progressive weight regain after medication cessation, with regain averaging approximately 0.4 kg/month and cardiometabolic markers projected to return toward baseline within approximately 1.4 years after discontinuation
Semaglutide does have several potentially serious side effects
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TRIUMPH-CVOT: cardiovascular outcomes trial, approximately 10,000 participants with established CVD, primary endpoint major adverse cardiovascular events (MACE), timeline 3 to 4 years
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