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On the other hand, non-enzymatic antioxidants include glutathione (GSH), vitamins (such as vitamin C and vitamin E), selenium, and metabolites (including bilirubin and melatonin)
Carnitine also serves a critical buffering function by accepting excess acyl groups that accumulate during periods of high metabolic flux (intense exercise, fasting)
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The emergence of clinically effective dual and triple agonists holds promise for enhanced metabolic outcomes, although the precise mechanisms of drug actions remain to be fully elucidated
