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Jabri, B
Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)
Fitzpatrick MF, Engleman HM, Boellert F, McHardy R, Shapiro CM, Deary IJ, Douglas NJ (1992) Effect of therapeutic theophylline levels on the sleep quality and daytime cognitive performance of normal subjects
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