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41 Slc3a2-dependent BCAA metabolism also has a key role in the physiological activities of Foxp3 + Treg cells, and either BCAA deprivation or SLC3A2 mutation can induce impaired activation of the mTORC1 pathway in Treg cells and inhibit the immunosuppressive function of Treg cells

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This process involves a breakdown of the cell membrane, leading to cell swelling, rupture of organelles, and the spilling of cellular contents into the surrounding space, which in turn sparks an inflammatory response in nearby tissues

JCI Insight 4 , e129793 (2019)

Muscle function magnesium is essential for muscle contraction and relaxation