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Specifically, in the group of patients prescribed semaglutide for weight loss, 6.7% developed NAION compared to just 0.8% of those on other treatments
Topiramate may increase semaglutide-related gastrointestinal effects, and semaglutide may compound topiramate's neurological side effects
Role of GLP-1 and Amylin in Sustained Energy Balance
Side effects may last for weeks after the last dose is taken
Case reports exist of palpitations and faster heart rate, and postmarketing data include rare arrhythmia reports, so clinicians weigh pulse changes against cardiovascular risk reduction seen in many trial populations
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