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On the contrary, miR-138 (192), miR-142-3p (198), miR-98 (201), miR-26a-5p (203), miR-191 (205), miR-15 (222), and miR-483-3p (282) enhance the inflammatory milieu and subsequently tissues could be damaged
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It requires sterile technique, causes discomfort for needle-averse individuals, creates potential injection site reactions, and demands careful rotation to avoid tissue damage over extended protocols
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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes
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