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Multicenter randomized trials have shown that saxagliptin as monotherapy, as initial therapy with metformin or as add-on therapy with metformin, a sulfonylurea or a thiazolidinedione leads to significant decreases in glycated hemoglobin levels, fasting and postprandial plasma glucose levels and higher percentages of patients attaining target glycated hemoglobin of less than 7% compared with controls.

The pathogenesis of parkinsons disease: a complex interplay between astrocytes, microglia, and T lymphocytes

doi: 10.3389/fcell.2018.00137 154 Ferreira-MarquesMCarvalhoACavadasCAveleiraCA

For doses up to 50 units (0.5 mL), use a 0.5 mL U-100 insulin syringe with a 31-gauge, 5/16-inch needle