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Liver disease can disrupt SAM production, SAH disposal and the normal balance between methyl-group supply and demand
Elderly patients tend to have a greater frequency of decreased hepatic, renal, or cardiac function, and also have concomitant disease or receiving other drug therapy
The closest low-exposure anchor is ONeil 2018, where daily injections totaling roughly 0.35 mg per week produced measurable weight loss over 52 weeks. That supports low-exposure activity, not a tested weekly microdose protocol
Healthcare providers may recommend an initial treatment period of 4-6 weeks with 1-3 doses per week [21]
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