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VMAT2 exploits this H gradient via protonmonoamine exchange to actively transport cytosolic monoamines into the vesicle against their concentration gradient, enabling vesicular storage and subsequent regulated neurotransmitter release
50 Peklak-ScottC.SmithermanP
Fernando champions at least two servings of fatty fish a week, adding flax and chia seeds to your smoothies or oatmeal, and snacking on walnuts in the afternoon
In a statement to Insider, Novo Nordisk, the company that makes Wegovy and Ozempic, said that Gila monsters and the discovery of exendin-4 "did not have anything to do with our decision to develop long-acting GLP-1 receptor agonists" for obesity, because "that was based on GLP-1 biology in humans." But the company also said that "the GLP-1-like effect of exendin-4" in Gila monsters was "an important contribution to the field," as it led to the development of the very first injectable drug of its kind
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