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Keen to prove the sceptics wrong, Brown set off on a quest to isolate the substance which he named 'gastric inhibitory polypeptide' or GIP (Kieffer)

Intact protein mass spectrometry Following proteolysis, reactions were diluted to 100 ng l 1 in 25 mM HEPES (pH 7.5), 10 mM MgCl 2 and 150 mM NaCl

This process is called homocysteine metabolism

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In Hashimotos thyroiditis, in addition to the cellular response, the humoral response is prominent, with anti-TPO antibodies correlating with lymphocyte infiltration into the thyroid gland