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It has been reported that treatment with the GLP-1R agonist exendin-4 did not affect the proliferation or survival of human pancreatic cancer cell lines (4), while other authors reported that treatment with the GLP-1R agonist liraglutide had an antitumorigenic effect on human pancreatic cancer cells in vitro and in vivo (5,6)
On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes
The sequence, formulation, dose, route, tissue concentration and duration all matter
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