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Step 1: Dietary and lifestyle changes Increase soluble fiber gradually to 25-30 grams per day (psyllium husk, oats, chia seeds, ground flaxseed) Drink 64-80 oz of water daily, spread throughout the day Add prunes or prune juice (4-6 prunes or 4-8 oz juice daily) Increase physical activity, especially walking (stimulates colonic motility) Establish a consistent bathroom routine (same time each day, usually 20-30 minutes after breakfast) About 40% of patients with mild GLP-1 constipation see improvement within 7-10 days of consistent dietary changes alone

The first week, I noticed sleep improved because my shoulders stopped throbbing every time I rolled over

not having reached the target dose at a prespecified week

The peptide appears to reduce mucosal inflammation, accelerate intestinal healing, and restore intestinal barrier function

Subsequently, beneficial effects of FOXO4-DRI have been demonstrated in various age-related models 6,7,8