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The extrinsic pathway is known to respond to external stimuli and is triggered by the binding of ligands to membrane death receptors, mainly belonging to the tumor necrosis factor receptor (TNFR) superfamily that overall lead to the activation of caspases-8 or -3 (Bodmer et al., 2005
Some GI adjustment (mild nausea, fullness) is normal and passes within 2-4 weeks
IL-17 family cytokines are two-fold, as they can induce cells to secrete active molecules to promote the bodys resistance to infection
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