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Patients with active suicidal ideation, recent psychiatric hospitalization, or unstable bipolar disorder should not start a GLP-1 agent through any telehealth platform without documented coordination with their treating psychiatrist

[8] [9] Nevertheless, any medication that affects appetite, weight, and metabolic function may have secondary effects on mood and overall mental health, which is why monitoring remains important

While improvements in diet and physical activity might explain some of the overall improvement, they do not account for the differences observed between the active and placebo groups

Consistent with this, we show the G protein can allosterically influence GLP-1R agonist affinity, but this occurs in a peptide-dependent manner

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