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This approval came after the SCALE Trial showed that high dose liraglutide not only better prevented progression from prediabetes to diabetes (as compared to placebo), but also had a threefold impact on weight loss
Preserving it maintains a higher calorie burn at rest, which directly supports long-term weight maintenance after the medication is discontinued
MOTS-c passed 7 to 5
Common gastrointestinal complaints like nausea and vomiting are typical early with GLP-1 agonists, often diminishing over weeks with dose titration and regular monitoring
Writing Group for the CKD Prognosis Consortium et al
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