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Long-term human safety data does not exist, which is the main caution
Sophie Dix (BSc, PhD) Published: 9 February 2026 | Updated: 7 May 2026 Updated: 7 May 2026 Reading time: 8 minutes Quick navigation: Weight management is just one part of the picture when it comes to your health
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[10] [11] This risk is relevant to retatrutide given its significant weight-loss effect, and patients should be aware of related symptoms (see 'When to Seek Medical Advice' below)
Dehydration can, in rare cases, lead to kidney problems
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