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There has been varying signals in the literature to date, but it seems like for many people taking it anywhere from 10-50% of the weight lost is muscle weight
The 20.7% figure comes from the STEP-UP trial of 1,742 adults living with obesity, published in NEJM in 2025
Some providers will prescribe below BMI 27 based on clinical judgment
Boronic acid-based arginase inhibitors in cancer immunotherapy
Both medication types also commonly influence appetite and weight, as they act on overlapping hormonal and reward pathways in the brain (Srinivasan et al., 2025)
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