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71 In HPP, deficiency or dysfunction of TNSALP disrupts the metabolism of PLP leading to alteration of both extracellular and intracellular PLP levels
The oxidized GSSG is then recycled by GSH reductase, sustaining a high intracellular GSH/GSSG ratio
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Contraindications or cautions include uncontrolled hypertension, cardiac arrhythmias, history of coronary artery disease, hyperthyroidism, or psychiatric conditions sensitive to stimulants
Much of the focus on the impact of GLP-1 receptor agonists (and combination drugs with components that target other receptors such as gastric inhibitory polypeptide collectively termed GLP-1s in this article) to date has been on their potential to improve long-term health outcomes for people with type 2 diabetes, obesity, and related cardiovascular diseases
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