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Extracellular histones induce erythrocyte fragility and anemia

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Nature , 288(5792), 715717

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GHK-Cu acts at the extracellular matrix (ECM) level, modulating the balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) to regulate collagen turnover, and stimulating fibroblasts to produce collagen type I, collagen type III, and elastin