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The full publication is available for free download for the next 50 days: #PulmonaryHypertension #ChronicKidneyDisease #CardiovascularEvents #RHC Association of borderline pulmonary artery wedge pressure with major cardiovascular events in patients with pulmonary hypertension and chronic kidney disease sciencedirect.com To view or add a comment, sign in CHRONIC MULTI-SYTEM DISEASES ACE2 Loss, GPCRs, and -Arrestin: The Epigenetic Storm Behind Chronic Multi-System Disease When ACE2 levels drop (due to SARS-CoV-2, EBV/Zta, or chronic stress), it sets off a cascade of GPCR overactivation: Angiotensin II / AT1R vasoconstriction, inflammation, oxidative stress Bradykinin / B1R pain, vascular permeability, inflammation Tachykinins / NK1R neuroinflammation, pain, autonomic dysregulation Prostaglandins / EP & DP receptors amplifies PGE2/PGD2-driven inflammatory signaling These GPCRs hyperactivate intracellular pathways like NF-B, MAPK/ERK, CREB, and JAK/STAT leading to epigenetic reprogramming

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Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma