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This was reported in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose, compared to just 0.7% on placebo

Even though we confirmed that astrocyte activation induces lactate release in the extracellular space, we cannot exclude that other mechanisms might be activated by optogenetic stimulation of astrocytes

This results in B12 malabsorption, deficiency, and megaloblastic (abnormally large and dysfunctional) RBCs in many cases

The randomized controlled trial is needed

At the same time, we need to be aware that GLP-1s appear to elevate the risk of age-related macular degeneration (AMD) in patients with diabetes (4)