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This has driven interest in oral formulations and alternative delivery systems, which are seen as potential solutions to improve accessibility and adherence

, (MET)(SU)(TZD)DPP-4(DPP-4i)SGLT-2(SGLT-2i), GLP-1(GLP-1RA),

Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing food intake Acting on appetite centres in the brain to decrease hunger signals Microdosing refers to the practice of using substantially lower doses of a medication than those typically prescribed for its licensed indications

It therefore has no direct effect on weight loss

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