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1 Introduction Parkinsons disease (PD) ranks as the second most common neurodegenerative disorder, primarily manifesting through hallmark motor symptoms such as tremor, bradykinesia, postural instability, and rigidity, with non-motor symptoms including sleep disturbances, olfactory deficits, cognitive impairments, and depression often predating the motor manifestations (Madiha et al., 2021)

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WEDNESDAY, May 13, 2026 (HealthDay News) -- Treatment with semaglutide significantly improves measures of motivation in patients with major depressive disorder (MDD), according to a study published April 29 in JAMA Psychiatry.Hartej Gill, Ph.D., from University of Toronto, and colleagues assessed the effects of semaglutide, on reward-related dysfunction in a population with MDD