However, it's important to note that the long-term effects of IF are still not fully understood, and there's some debate about whether IF is superior to continuous caloric restriction, as typically used with semaglutide medication, regarding health and weight loss benefits [4, 7]
When these drugs were being developed, researchers observed that rats and mice exposed to high doses of GLP-1 RAs developed an increased incidence of C-cell hyperplasia (an overgrowth of specific thyroid cells) and medullary thyroid tumours
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This is one reason the core published evidence for cagrilintide is presented as percent change in body weight over 26 weeks in the main phase 2 trial
And they want to essentially remove the restrictions the FDA put in place that have kept compounding pharmacies, sort of independent pharmacies, from making these drugs. This interview was edited for clarity