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In the scenario of cobalamin deficiency, the methylation of Hcy to methionine will essentially lead to an excessive turnover of Choline resulting in a posited cholinergic deficiency

It is essential to distinguish medically indicated B12 replacement therapy from commercially marketed wellness injections, as they serve fundamentally different purposes and are subject to different regulatory oversight

Topical and Nasal AOD-9604 Topical and nasal forms appear in marketing, but the FDA review found no published human exposure data for transdermal or intranasal AOD-9604

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