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Conversely, strong CYP3A inducers (such as rifampin, phenytoin, and carbamazepine) could reduce orforglipron exposure below therapeutic levels
It suggests that even well-designed compounds with plausible mechanisms and positive animal data may not translate to human benefit
Duncan says
Pharmaceutical companies knew their drugs could cause serious, life-altering injuries, and they failed to adequately warn patients and doctors about those risks
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