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The rebound effect reflects how deeply GLP-1 medications influence appetite regulation centers in the hypothalamus
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The Lancet, 394(10192), 39-50
Notably, many trial participants had sedentary lifestyles or reported minimal exercise, yet still achieved these results, confirming that appetite suppression alone drives significant metabolic change
Alternatively, if acetylcysteine is not being utilized, then bicarbonate may be used to support the pH until pyroglutamic acid can be metabolized
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