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In NOD mice, treatment with the DPP4 inhibitor MK0431 prolonged the survival of islet grafts and reduced CD4+ T cell migration into the pancreas through the cAMP/PKA/Rac1 activation pathway

Rather than dismissing or criticizing patients for their choices, clinicians should objectively evaluate potential risks, verify exactly what the patient is taking, and develop a safe, evidence-based treatment plan that preserves trust while strengthening the therapeutic relationship

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