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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig

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The MTHFD1L encoded enzyme is a mono-functional enzyme with 10-formyl-THF synthetase activity and the MTHFD2L encoded enzyme is a bi-functional enzyme with 5,10-methylene-THF dehydrogenase and 5,10-methenyl-THF cyclohydrolase activities

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