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A recent proteomic study suggested altered mitochondrial function in the cerebrovasculature isolated from deceased cognitively healthy E4 carriers compared to non-E4 carriers, indicating that cerebrovascular bioenergetics may indeed be altered in cognitively healthy E4 carriers (Ojo et al., 2021)

Furthermore, the study demonstrated functional clinical benefits: natural killer (NK) cell cytotoxicity, a vital marker of immune system strength, increased more than twofold in the high-dose cohort

Zhou T, Zhang M, Zhao L, Li A, Qin X

Furthermore, it has anti-inflammatory properties

and production and release of cytokines