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Biomaterials 16:905910 Waters RV, Gamradt SC, Asnis P, Vickery BH, Avnur Z, Hill E, Bostrom M (2000) Systemic corticosteroids inhibit bone healing in a rabbit ulnar osteotomy model

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These can result in local infections, systemic inflammation, or unexpected endocrine consequences

Look for CreaPure certification (produced by Alzchem, Germany) as a purity benchmark, or an independent COA showing greater than 99.9% creatine with creatinine below 100 ppm