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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

Under physiological conditions, T-cell trafficking and infiltration proceed through a multistep cascade comprising tethering, rolling, arrest, transendothelial migration, and chemokine-guided interstitial navigation

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